Endotoxin-induced uveitis in rats as a model for human disease

@article{Rosenbaum1980EndotoxininducedUI,
  title={Endotoxin-induced uveitis in rats as a model for human disease},
  author={James T. Rosenbaum and Hugh O Mcdevitt and R. B. Guss and Peter R. Egbert},
  journal={Nature},
  year={1980},
  volume={286},
  pages={611-613}
}
Acute anterior uveitis is a relatively common disease of uncertain aetiology. Its association with a wide variety of systemic disorders including ankylosing spondylitis, Reiter's syndrome, Behçet's disease, juvenile rheumatoid arthritis, psoriatic arthritis, inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 (ref. 1) in cases without associated disease have been noted but not explained. In general, animal models for uveitis have not clarified the mechanism of… CONTINUE READING
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Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
The studies described below indicate that the eye disease is due to a portion of the bacterial cell wall known as endotoxin or lipopolysaccharide ( LPS ) .
The studies described below indicate that the eye disease is due to a portion of the bacterial cell wall known as endotoxin or lipopolysaccharide ( LPS ) .
The studies described below indicate that the eye disease is due to a portion of the bacterial cell wall known as endotoxin or lipopolysaccharide ( LPS ) .
The studies described below indicate that the eye disease is due to a portion of the bacterial cell wall known as endotoxin or lipopolysaccharide ( LPS ) .
The studies described below indicate that the eye disease is due to a portion of the bacterial cell wall known as endotoxin or lipopolysaccharide ( LPS ) .
The studies described below indicate that the eye disease is due to a portion of the bacterial cell wall known as endotoxin or lipopolysaccharide ( LPS ) .
RetinaSibling in part ofUvea
Most require direct intravitreal injection2 or repeated immunizations with retinal or uveal antigens3 .
UveaSibling in part ofRetina
Most require direct intravitreal injection2 or repeated immunizations with retinal or uveal antigens3 .
RetinaNo subtypeUvea
Most require direct intravitreal injection2 or repeated immunizations with retinal or uveal antigens3 .
UveaNo subtypeRetina
Most require direct intravitreal injection2 or repeated immunizations with retinal or uveal antigens3 .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
Its association with a wide variety of systemic disorders including ankylosing spondylitis , Reiter 's syndrome , Behçet 's disease , juvenile rheumatoid arthritis , psoriatic arthritis , inflammatory bowel disease and sarcoidosis and the prevalence of the HLA antigen B27 ( ref .
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