Endotoxin-induced shock in the rat. A role for C5a.

Abstract

Administration of endotoxin from gram-negative bacteria to rats results in systemic hypotension, an increased hematocrit, and decreased numbers of circulating leukocytes (polymorphonuclear), monocytes, and platelets. These potentially lethal physiologic changes may be partially attributed to complement activation and generation of anaphylatoxins by the… (More)

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@article{Smedegrd1989EndotoxininducedSI, title={Endotoxin-induced shock in the rat. A role for C5a.}, author={G{\"o}ran Smedeg{\aa}rd and L. X. Cui and Tony E. Hugli}, journal={The American journal of pathology}, year={1989}, volume={135 3}, pages={489-97} }