Endotoxin-induced shock in the pig--limited effects of low and high concentrations of inhaled nitric oxide.

Abstract

AIM This study was carried out to study the prophylactic effects of inhalation of nitric oxide (NO) before and during the induction of endotoxic shock. METHODS Eighteen anaesthetized pigs received an infusion of 10-20 microg kg(-1) endotoxin during 2 h after pre-treatment with the cortisol-synthesis inhibitor metyrapone. Three groups were tested (n = 6… (More)

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