Endotoxin-induced release of interleukin-6 from rat medial basal hypothalami.

  title={Endotoxin-induced release of interleukin-6 from rat medial basal hypothalami.},
  author={Bryan L. Spangelo and Allan M. Judd and Robert M. Macleod and D W Goodman and Peter C. Isakson},
  volume={127 4},
Interleukin-6 (IL-6) is an inflammatory cytokine that stimulates T-cell activation and B-cell differentiation. We recently reported that picomolar concentrations of IL-6 stimulated PRL, GH, and LH release in vitro. These data suggested that IL-6 may function as a hypothalamic releasing factor for anterior pituitary hormones. Medial basal hypothalami (MBH) were incubated for 60-90 min in Krebs-Ringer bicarbonate buffer supplemented with 0.025% BSA, and the conditioned medium was assayed for IL-6… 

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