Endotoxin-induced nitric oxide production in pulmonary artery endothelial cells is regulated by cytokines.

@article{Cendan1994EndotoxininducedNO,
  title={Endotoxin-induced nitric oxide production in pulmonary artery endothelial cells is regulated by cytokines.},
  author={Juan Cendan and Lyle L. Moldawer and Wiley W. Souba and Edward M. Copeland and D. Scott Lind},
  journal={Archives of surgery},
  year={1994},
  volume={129 12},
  pages={1296-300}
}
BACKGROUND L-Arginine is the sole precursor of nitric oxide (NO). Bacterial lipopolysaccharide (endotoxin) (LPS) stimulates carrier-mediated L-arginine transport in porcine pulmonary artery endothelial cells (PAECs) through an autocrine pathway that involves interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF-alpha). OBJECTIVES To determine if Escherichia coli LPS stimulates NO synthesis in PAECs and, if so, if LPS stimulation of NO production is also mediated by autocrine… CONTINUE READING
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