Endotoxin-induced ileal mucosal hyperpermeability in pigs: role of tissue acidosis.

  title={Endotoxin-induced ileal mucosal hyperpermeability in pigs: role of tissue acidosis.},
  author={Andrew L. Salzman and Haichao Wang and P S Wollert and T J Vandermeer and Carolyn C. Compton and Alvin G. Denenberg and Mitchell P. Fink},
  journal={The American journal of physiology},
  volume={266 4 Pt 1},
Administration of lipopolysaccharide (LPS) to experimental animals leads to diminished mesenteric perfusion, increased ileal mucosal [H+] , and increased gut epithelial permeability to hydrophilic solutes. We sought to determine whether these phenomena are causally related. Experiments were performed in anesthetized pigs. Permeability was assessed by measuring the plasma-to-lumen clearance of fluorescein isothiocyanate dextran (4,000 Da; FD-4) by a segment of ileum perfused with Ringer lactate… CONTINUE READING


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