Endotoxin-induced HIF-1α stabilisation in equine endothelial cells: synergistic action with hypoxia

@article{Brooks2010EndotoxininducedHS,
  title={Endotoxin-induced HIF-1α stabilisation in equine endothelial cells: synergistic action with hypoxia},
  author={Andrew C Brooks and N J Menzies-Gow and S R Bailey and Fiona M Cunningham and John Elliott},
  journal={Inflammation Research},
  year={2010},
  volume={59},
  pages={689-698}
}
Hypoxia may enhance the deleterious effects of lipopolysaccharide (LPS) in the endotoxaemic horse. This study has examined some of the actions of LPS and hypoxia, alone and in combination, on cultured equine digital vein endothelial cells (EDVEC) and the signalling molecules involved. EDVEC were exposed to LPS, 5% O2 and LPS then 5% O2 for up to 24 h. HIF-1α stabilisation, neutrophil adhesion and EDVEC permeability were assessed by immunoblotting, measurement of myeloperoxidase and movement of… CONTINUE READING

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