Endotoxin desensitization of human mononuclear cells after cardiopulmonary bypass: role of humoral factors.

@article{Grundmann2000EndotoxinDO,
  title={Endotoxin desensitization of human mononuclear cells after cardiopulmonary bypass: role of humoral factors.},
  author={Ulrich Grundmann and Hauke Rensing and Hans Anton Adams and Sandor Falk and Olaf Wendler and Nina Ebinger and Mirco Bauer},
  journal={Anesthesiology},
  year={2000},
  volume={93 2},
  pages={
          359-69
        }
}
BACKGROUND The ability of leukocytes to release proinflammatory cytokines on lipopolysaccharide stimulation in vitro is impaired after cardiopulmonary bypass (CPB). This study tested contribution and interaction of humoral factors in altered leukocyte responsiveness to lipopolysaccharide. METHODS Whole blood and isolated peripheral-blood mononuclear cells (PBMCs) from 10 patients obtained after induction of anesthesia (T1) and 20 min (T2) and 24 h (T3) after CPB were cultured in the absence… CONTINUE READING

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