Endotoxin depresses heart rate variability in mice: cytokine and steroid effects.

@article{Fairchild2009EndotoxinDH,
  title={Endotoxin depresses heart rate variability in mice: cytokine and steroid effects.},
  author={Karen D. Fairchild and Jeffrey J. Saucerman and Laura L. Raynor and Joseph A. Sivak and Yuping Xiao and Douglas E. Lake and J. Randall Moorman},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2009},
  volume={297 4},
  pages={R1019-27}
}
Heart rate variability (HRV) falls in humans with sepsis, but the mechanism is not well understood. We utilized a mouse model of endotoxemia to test the hypothesis that cytokines play a role in abnormal HRV during sepsis. Adult male C57BL/6 mice underwent surgical implantation of probes to continuously monitor electrocardiogram and temperature or blood pressure via radiotelemetry. Administration of high-dose LPS (Escherichia coli LPS, 10 mg/kg, n = 10) caused a biphasic response characterized… CONTINUE READING