Endotoxin and nanobacteria in polycystic kidney disease.

  title={Endotoxin and nanobacteria in polycystic kidney disease.},
  author={J. Thomas Hjelle and Marcia A. Miller-Hjelle and Ian R. Poxton and E. Olavi Kajander and Neva Ciftcioglu and Mitchell Jones and Robert C Caughey and Rhubell Brown and P D Millikin and Franck Darras},
  journal={Kidney international},
  volume={57 6},
BACKGROUND Microbes have been suspected as provocateurs of polycystic kidney disease (PKD), but attempts to isolate viable organisms have failed. Bacterial endotoxin is the most often reported microbial product found in PKD fluids. We assessed potential microbial origins of endotoxin in cyst fluids from 13 PKD patients and urines of PKD and control individuals. METHODS Fluids were probed for endotoxin and nanobacteria, a new bacterium, by the differential Limulus Amebocyte Lysate assay (dLAL… CONTINUE READING
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