Endotoxin and ischemic preconditioning: TNF-alpha concentration and myocardial infarct development in rabbits.

@article{Belosjorow1999EndotoxinAI,
  title={Endotoxin and ischemic preconditioning: TNF-alpha concentration and myocardial infarct development in rabbits.},
  author={Sergej Belosjorow and Richard Schulz and Hilmar D{\"o}rge and Fritz Ulrich Schade and Gerd Heusch},
  journal={The American journal of physiology},
  year={1999},
  volume={277 6},
  pages={
          H2470-5
        }
}
Ischemic preconditioning (IP) and prior exposure to lipopolysaccharides (LPS) reduce infarct size (IS) and serum tumor necrosis factor-alpha (TNF-alpha) concentration resulting from myocardial ischemia-reperfusion in rabbits. The decrease in TNF-alpha might relate to an induced TNF-alpha inhibitory serum activity (TNF-alpha-ISA). We analyzed TNF-alpha and TNF-alpha-ISA during 30 and 180 min ischemia and reperfusion, respectively, in anesthetized rabbits either untreated (group 1, n = 7… CONTINUE READING
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