Endotoxin and TNF lead to reduced plasma LCAT activity and decreased hepatic LCAT mRNA levels in Syrian hamsters.

@article{Ly1995EndotoxinAT,
  title={Endotoxin and TNF lead to reduced plasma LCAT activity and decreased hepatic LCAT mRNA levels in Syrian hamsters.},
  author={Hinh Ly and Omar L. Francone and Christopher J. Fielding and Judy K. Shigenaga and Arthur H. Moser and Carl Grunfeld and Kennenth R Feingold},
  journal={Journal of lipid research},
  year={1995},
  volume={36 6},
  pages={1254-63}
}
Endotoxin (LPS) administration, which mimics infection, stimulates the production of many cytokines, including TNF, that are thought to mediate the alterations in lipid metabolism that occur during infection. The aims of this study were to determine the effect of LPS or TNF administration on plasma LCAT activity and hepatic LCAT mRNA levels in Syrian hamsters. Plasma LCAT activity was decreased 8 h after LPS administration, reached a maximum level of inhibition at 16 h which persisted for at… CONTINUE READING

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