Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation

@inproceedings{Huizinga2012EndotoxinAA,
  title={Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation},
  author={Ruth Huizinga and Karim L. Kreft and Sabina Onderwater and Joke G. Boonstra and R. M. Munoz Brands and Rogier Q. Hintzen and Jon D Laman},
  booktitle={Journal of Neuroinflammation},
  year={2012}
}
Alkaline phosphatase (AP) is a ubiquitously expressed enzyme which can neutralize endotoxin as well as adenosine triphosphate (ATP), an endogenous danger signal released during brain injury. In this study we assessed a potential therapeutic role for AP in inhibiting neuroinflammation using three complementary approaches. Mice were immunized to induce… CONTINUE READING