Endotoxin-Induced Myocardial Tumor Necrosis Factor-a Synthesis Depresses Contractility of Isolated Rat Hearts Evidence for a Role of Sphingosine and Cyclooxygenase-2–Derived Thromboxane Production

Abstract

Background—Although endotoxin (lipopolysaccharides, LPS) is recognized as a mediator of septic cardiodepression, its cardiac effects are still not fully elucidated. Methods and Results—Perfusion of isolated rat hearts with LPS for 180 minutes resulted in a decline of left ventricular contractility after 90 minutes, whereas coronary perfusion pressure… (More)

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@inproceedings{Grandel2000EndotoxinInducedMT, title={Endotoxin-Induced Myocardial Tumor Necrosis Factor-a Synthesis Depresses Contractility of Isolated Rat Hearts Evidence for a Role of Sphingosine and Cyclooxygenase-2–Derived Thromboxane Production}, author={Ulrich Grandel and Martina Heep and Michael Buerke and Rainer Bohle}, year={2000} }