Endotoxemia is Associated With Partial Uncoupling of Cardiac Pacemaker From Cholinergic Neural Control in Rats

@article{Gholami2012EndotoxemiaIA,
  title={Endotoxemia is Associated With Partial Uncoupling of Cardiac Pacemaker From Cholinergic Neural Control in Rats},
  author={Masoumeh Gholami and P. Mazaheri and Amin Mohamadi and Tara Dehpour and F. Safari and S. Hajizadeh and K. Moore and A. Mani},
  journal={Shock},
  year={2012},
  volume={37},
  pages={219–227}
}
ABSTRACT Cardiac cycle is regulated by a complex interplay between autonomic nervous system and cardiac pacemaker cells. Decreased heart rate variability (HRV) and increased cardiac rhythm regularity are associated with poor prognosis in patients with systemic inflammation (e.g., sepsis). However, the underlying mechanism of decreased HRV in systemic inflammation is not understood. It is known that greater regularity in a complex system could indicate uncoupling of the system’s components. The… Expand
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