Endothelium-neutrophil interactions in ANCA-associated diseases.

@article{Halbwachs2012EndotheliumneutrophilII,
  title={Endothelium-neutrophil interactions in ANCA-associated diseases.},
  author={Lise Halbwachs and Philippe Lesavre},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2012},
  volume={23 9},
  pages={1449-61}
}
The two salient features of ANCA-associated vasculitis (AAV) are the restricted microvessel localization and the mechanism of inflammatory damage, independent of vascular immune deposits. The microvessel localization of the disease is due to the ANCA antigen accessibility, which is restricted to the membrane of neutrophils engaged in β2-integrin-mediated adhesion, while these antigens are cytoplasmic and inaccessible in resting neutrophils. The inflammatory vascular damage is the consequence of… CONTINUE READING
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