Endothelium-independent vasodilation effect of di- and tri-peptides in thoracic aorta of Sprague-Dawley rats.

@article{Tanaka2008EndotheliumindependentVE,
  title={Endothelium-independent vasodilation effect of di- and tri-peptides in thoracic aorta of Sprague-Dawley rats.},
  author={Mitsuru Tanaka and Mai Tokuyasu and Toshiro Matsui and Kiyoshi Matsumoto},
  journal={Life sciences},
  year={2008},
  volume={82 15-16},
  pages={869-75}
}
The goal of this study was to elucidate the structure-activity relationship for vasodilating peptides and their underlying mechanism. In this study, we synthesized 62 di- and tri-peptides having aromatic amino acid residues (Tyr, Trp and Phe). Among them, only 4 peptides (HW, WH, WL and WV) evoked an apparent vasodilating effect in 50 mM KCl-contracted aortic rings in the descending order of WH>HW>WL>WV; WH showed the vasodilating activity with an EC50 of 3.4 mM. Within our experimental results… CONTINUE READING