• Corpus ID: 24575948

Endothelium-independent and endothelium-dependent contractions mediated by P2X- and P2Y-purinoceptors in canine basilar arteries.

  title={Endothelium-independent and endothelium-dependent contractions mediated by P2X- and P2Y-purinoceptors in canine basilar arteries.},
  author={Hiroaki Shirahase and Hachiro Usui and H. Shimaji and Kazuyoshi Kurahashi and Motohatsu Fujiwara},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={256 2},
Both alpha, beta-methylene ATP and beta, gamma-methylene ATP (P2X selective agonists) were shown to induce transient contraction in intact and endothelium-removed preparations of canine basilar arteries. 2-Methylthio ATP (a P2Y selective agonist) caused transient contraction of intact arteries and this response was nearly abolished by removal of the endothelium. In the presence of alpha, beta-methylene ATP (10(-6) M), the endothelium-independent contractions induced by alpha, beta-methylene ATP… 
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