Endothelium dysfunction in LDL receptor knockout mice: a role for H2O2.

  title={Endothelium dysfunction in LDL receptor knockout mice: a role for H2O2.},
  author={Luiza Antas Rabelo and Steyner França C{\^o}rtes and Jacqueline Isaura Alvarez-Leite and Virg{\'i}nia Soares Lemos},
  journal={British journal of pharmacology},
  volume={138 7},
1. In this study, the role of endogenous H(2)O(2) as an endothelium-dependent relaxant factor was characterised in aortas from C57BL/6J and LDL receptor-deficient mice (LDLR(-/-)). 2. Aortic rings from LDLR(-/-) mice showed impaired endothelium-dependent relaxation to acetylcholine (ACh; 0.001-100 micro M) and to the Ca(2+) ionophore A23187 (0.001-3 micro M) compared with aortic rings from control mice. Endothelium-independent relaxation produced by the NO donor, 3-morpholino-sydnonimine (SIN-1… CONTINUE READING
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