Endothelium-derived vasoactive agents, AT1 receptors and inflammation.

@article{Mackenzie2011EndotheliumderivedVA,
  title={Endothelium-derived vasoactive agents, AT1 receptors and inflammation.},
  author={Andrew G Mackenzie},
  journal={Pharmacology & therapeutics},
  year={2011},
  volume={131 2},
  pages={
          187-203
        }
}
Angiotensin II, through activation of the angiotensin II-type 1 receptor, induces generation of inflammatory mediators in the blood vessel wall and as such plays an active role in the inflammation process. Direct stimulation of reactive oxygen species and nuclear factors seem to be key mechanisms through which this receptor induces inflammation. Inflammatory molecules are also known to modify endothelial cell function, especially endothelium-derived vasoactive agents, and inflammation is… CONTINUE READING
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