Endothelium-derived reactive oxygen species: their relationship to endothelium-dependent hyperpolarization and vascular tone.

@article{Ellis2003EndotheliumderivedRO,
  title={Endothelium-derived reactive oxygen species: their relationship to endothelium-dependent hyperpolarization and vascular tone.},
  author={Anthie Ellis and Christopher R. Triggle},
  journal={Canadian journal of physiology and pharmacology},
  year={2003},
  volume={81 11},
  pages={1013-28}
}
Opinions on the role of reactive oxygen species (ROS) in the vasculature have shifted in recent years, such that they are no longer merely regarded as indicators of cellular damage or byproducts of metabolism--they may also be putative mediators of physiological functions. Hydrogen peroxide (H2O2), in particular, can initiate vascular myocyte proliferation (and, incongruously, apoptosis), hyperplasia, cell adhesion, migration, and the regulation of smooth muscle tone. Endothelial cells express… CONTINUE READING

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