Endothelium-derived hyperpolarizing factor activates Ca2+-activated K+ channels in porcine coronary artery smooth muscle cells.

@article{Hayabuchi1998EndotheliumderivedHF,
  title={Endothelium-derived hyperpolarizing factor activates Ca2+-activated K+ channels in porcine coronary artery smooth muscle cells.},
  author={Yasunobu Hayabuchi and Yutaka Nakaya and Shunichi Matsuoka and Yusuke Kuroda},
  journal={Journal of cardiovascular pharmacology},
  year={1998},
  volume={32 4},
  pages={642-9}
}
Although endothelium-derived hyperpolarizing factor (EDHF) activity has been demonstrated in arteries from various species, EDHF has not been chemically identified, nor its mechanism of action characterized. To elucidate this mechanism, we tested the effect of EDHF on large-conductance Ca2+-activated K+ (K(Ca)) channels in porcine coronary artery smooth muscle cells. By using a patch-clamp technique, single-channel currents were recorded in cultured smooth muscle cells; the organ bath also… CONTINUE READING

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