Endothelium-derived hyperpolarizing factor, but not nitric oxide or prostacyclin release, is resistant to menadione-induced oxidative stress in the bovine coronary artery

  title={Endothelium-derived hyperpolarizing factor, but not nitric oxide or prostacyclin release, is resistant to menadione-induced oxidative stress in the bovine coronary artery},
  author={Semiko Kaw and Markus Hecker},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  • S. Kaw, M. Hecker
  • Published 25 January 1999
  • Biology, Chemistry
  • Naunyn-Schmiedeberg's Archives of Pharmacology
The interaction of superoxide anions (O2–) generated by menadione with the synthesis and/or action of nitric oxide (NO), prostacyclin (PGI2) and endothelium-derived hyperpolarizing factor (EDHF) was investigated in segments of the left anterior descending coronary artery (LAD) isolated from bovine hearts. EDHF and NO release were monitored by superfusion bioassay in segments pre-constricted with the thromboxane mimetic, U46619, PGI2 release in addition by enzyme immunoassay for 6-keto… 
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