Endothelium-dependent vasomotor dysfunction in pig coronary arteries with Paclitaxel-eluting stents is associated with inflammation and oxidative stress.

@article{Pendyala2009EndotheliumdependentVD,
  title={Endothelium-dependent vasomotor dysfunction in pig coronary arteries with Paclitaxel-eluting stents is associated with inflammation and oxidative stress.},
  author={Lakshmana K Pendyala and Jinsheng Li and Toshiro Shinke and Sarah Geva and Xinhua Yin and Jack P. Chen and Spencer B. King and Keith A. Robinson and Nicolas A F Chronos and Dongming Hou},
  journal={JACC. Cardiovascular interventions},
  year={2009},
  volume={2 3},
  pages={253-62}
}
OBJECTIVES We sought to evaluate coronary epicardial and intramyocardial resistance, arterial vasomotor function, local inflammatory reaction, and superoxide anion (O(2)(.-)) production after overlapping paclitaxel-eluting stent (PES) implantation in a porcine model. BACKGROUND PES implantation has been shown to elicit coronary vasomotor dysfunction. However, underlying mechanisms remain largely unknown. METHODS Nine pigs received overlapping PES and bare-metal stents (BMS) in the coronary… CONTINUE READING
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