Endothelium-dependent vasodilation is attenuated in patients with heart failure.

  title={Endothelium-dependent vasodilation is attenuated in patients with heart failure.},
  author={Spencer H. Kubo and Thomas S. Rector and Alan J. Bank and Randall E Williams and Steven M. Heifetz},
  volume={84 4},
BACKGROUND Endothelial cells produce a number of substances, collectively termed endothelium-derived relaxing factor (EDRF), that promote local relaxation of vascular smooth muscle. Although studies have demonstrated defects in endothelium-dependent vasodilation in animal models of hypertension, atherosclerosis, and heart failure, there are only limited data from human subjects because of the difficulty in obtaining fresh vascular segments. METHODS AND RESULTS To address the hypothesis that… CONTINUE READING
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Limb vasodilator responsiveness to isoproterenol in congestive heart failure

  • MA Creager, RJ Quigg, C Ren, MA Meek, WS Colucci
  • JAm Coll Cardiol
  • 1990

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