Endothelium-dependent vascular smooth muscle control.

  title={Endothelium-dependent vascular smooth muscle control.},
  author={Masud Husain and Jonathan B Moss},
  journal={Journal of clinical anesthesia},
  volume={1 2},
Recent pharmacologic evidence supports the importance of the integrity of the endothelium in modulating vascular reactivity. The endothelial cells produce one or more endothelium derived relaxing factor(s) or EDRF that cause relaxation of vascular smooth muscle cells through production of cyclic guanosine monophosphate (GMP) and subsequent activation of protein kinase. While the molecular pharmacology of vascular relaxation is now well defined and numerous factors have been identified that… CONTINUE READING

Similar Papers

Loading similar papers…