Endothelium-dependent vascular effects of Pycnogenol.

  title={Endothelium-dependent vascular effects of Pycnogenol.},
  author={David F. Fitzpatrick and Bettye Bing and Peter Rohdewald},
  journal={Journal of cardiovascular pharmacology},
  volume={32 4},
Pycnogenol (P) is purported to exhibit effects that could be beneficial in terms of prevention of chronic age-related diseases such as atherosclerosis. The most studied of these effects is its antioxidant/free radical-scavenging activity. In this study, we investigated the possibility that this supplement might produce vascular effects by stimulation of nitric oxide (NO) production by vascular endothelial cells. In the in vitro experiments, P (1-10 microg/ml) relaxed epinephrine (E… CONTINUE READING


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