Endothelium-dependent responses of cerebral arterioles to adenosine 5'-diphosphate.

  title={Endothelium-dependent responses of cerebral arterioles to adenosine 5'-diphosphate.},
  author={William G Mayhan},
  journal={Journal of vascular research},
  volume={29 5},
The goal of this study was to determine the role of endothelium-derived relaxing factor (EDRF) in dilatation of cerebral arterioles in response to adenosine 5'-diphosphate (ADP). Using intravital microscopy, we measured the diameters of pial arterioles in vivo in rats during superfusion with ADP, acetylcholine and nitroglycerin before and during topical application of inhibitors of nitric oxide synthesis (NG-monomethyl-L-arginine; L-NMMA and NW-nitro-L-arginine; L-NNA). Prior to suffusion with… CONTINUE READING

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