Endothelium-dependent relaxations in the aorta from K(2p)6.1 knockout mice.

  title={Endothelium-dependent relaxations in the aorta from K(2p)6.1 knockout mice.},
  author={Eric E. Lloyd and Lavannya M. Pandit and Randy F. Crossland and Sean P. Marrelli and Robert M. Jr. Bryan},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={305 1},
K2P6.1 or TWIK-2, a two-pore domain K channel, is an important regulator of cardiovascular function. K2P6.1 is highly expressed in vascular smooth muscle and endothelium. Mice (8-12 wk) lacking functional K2P6.1 (K2P6.1(-/-)) are hypertensive and have enhanced vascular contractility. It is not known whether the lack of functional K2P6.1 in endothelium has a… CONTINUE READING