Endothelium-dependent relaxation induced by hawthorn extract in rat mesenteric artery.

  title={Endothelium-dependent relaxation induced by hawthorn extract in rat mesenteric artery.},
  author={Zhen-Yu Chen and Z S Zhang and Kenneth Y Kwan and Ming Hua Zhu and Walter K K Ho and Yu Huang},
  journal={Life sciences},
  volume={63 22},
The extract prepared from hawthorn (Crataegus fruit) was examined for its relaxant effect in rat isolated mesenteric arteries. Hawthorn extract induced concentration-dependent relaxation of the U46619-precontracted artery with an IC50 of 0.22 +/- 0.02 mg/ml. Removal of the functional endothelium reduced by approximately 85% the maximum relaxant response to hawthorn extract. Pretreatment of the arterial tissues with N(G)-nitro-L-arginine methyl ester (3-10 microM) or methylene blue (3-10 microM… CONTINUE READING


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