Endothelium-dependent relaxation in coronary arteries requires magnesium ions.

  title={Endothelium-dependent relaxation in coronary arteries requires magnesium ions.},
  author={Bella T. Altura and Burton M. Altura},
  journal={British journal of pharmacology},
  volume={91 3},
A great deal of interest has recently focused upon the mechanism(s) associated with the generation and action of endothelium-derived relaxant factors (EDRFs) in blood vessels. Since we have shown that extracellular magnesium ions ([Mg2+]o) are important in control of coronary vascular tone and reactivity, we wondered whether these divalent cations play any role in the generation or action of EDRF in coronary arterial smooth muscle. Using isolated canine coronary arterial rings, we have now… CONTINUE READING
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