Endothelium-dependent relaxation by uridine tri- and diphosphate in isolated human pial vessels.

@article{Hardebo1987EndotheliumdependentRB,
  title={Endothelium-dependent relaxation by uridine tri- and diphosphate in isolated human pial vessels.},
  author={Jan Erik Hardebo and Johan K̊ahrstr{\"o}m and C H Owman and Leif G. Salford},
  journal={Blood vessels},
  year={1987},
  volume={24 3},
  pages={150-5}
}
Uridine triphosphate (UTP) and uridine diphosphate (UDP) are present in platelets, probably linked to storage organelles. In several animal species, UTP is a powerful constrictor of cerebral arteries, with no detectable dilatory component, which was confirmed in the present study. When testing the vasomotor effects of UTP and UDP in precontracted isolated segments of human pial arteries it was found that these nucleotides were powerful, transient dilators in the concentration range 10(-7)-10(-5… CONTINUE READING

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