Endothelium-dependent regulation of vascular tone of the porcine ophthalmic artery.

@article{Yao1991EndotheliumdependentRO,
  title={Endothelium-dependent regulation of vascular tone of the porcine ophthalmic artery.},
  author={K Yao and Matthias Tschudi and J. Flammer and Thomas Felix L{\"u}scher},
  journal={Investigative ophthalmology & visual science},
  year={1991},
  volume={32 6},
  pages={1791-8}
}
The endothelium produces relaxing and contracting substances, among them nitric oxide and endothelin. The role of the endothelium was investigated in the regulation of vascular tone in isolated porcine ophthalmic arteries suspended in a myograph system for isometric tension recording. In quiescent arteries with endothelium, the inhibitor of nitric oxide formation from L-arginine, L-NG-monomethyl arginine (L-NMMA), evoked endothelium-dependent contractions which were reversed by L-, but not D… CONTINUE READING

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