Endothelium-dependent potentiation by cocaine of serotonin-induced contractions in sheep fetal umbilical artery.

@article{Zhang1998EndotheliumdependentPB,
  title={Endothelium-dependent potentiation by cocaine of serotonin-induced contractions in sheep fetal umbilical artery.},
  author={Lanjing Zhang and Xiang-Qun Hu},
  journal={Journal of the Society for Gynecologic Investigation},
  year={1998},
  volume={5 2},
  pages={
          72-4
        }
}
OBJECTIVE To evaluate the potential role of the endothelium in cocaine-mediated potentiation of serotonin-induced contractions of fetal ovine umbilical artery. METHODS Umbilical cords were isolated from near-term pregnant ewes (approximately 140 days). Serotonin-induced--dose-dependent contraction of the umbilical arteries was performed in the presence and absence of 3 mumol/L cocaine. The responses were compared before and after removal of the endothelium. RESULTS Cocaine (3 mumol/L… CONTINUE READING