Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery.

@article{Mey1982EndotheliumdependentIE,
  title={Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery.},
  author={Jo G. R. De Mey and Magda Claeys and Paul Michel Vanhoutte},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1982},
  volume={222 1},
  pages={166-73}
}
Experiments were designed to investigate the importance of endothelial metabolism of arachidonic acid in the relaxation of isolated arteries caused by acetylcholine, ATP, arachidonic acid itself and thrombin. Rings of canine femoral arteries were mounted for isometric tension recording in organ chambers filled with Krebs-Ringer-bicarbonate solution. Acetylcholine, arachidonic acid, ATP, 15-hydroperoxy-5,8,11,13 eicosatetraenoic acid, thrombin and prostacyclin caused relaxations of control rings… CONTINUE READING