Endothelium-dependent hyperpolarization: a role in the control of vascular tone.

@article{Garland1995EndotheliumdependentHA,
  title={Endothelium-dependent hyperpolarization: a role in the control of vascular tone.},
  author={Christopher J. Garland and Frances Plane and Barbara Kathryn Kemp and T. M. Cocks},
  journal={Trends in pharmacological sciences},
  year={1995},
  volume={16 1},
  pages={
          23-30
        }
}
Endothelial-dependent relaxation of vascular smooth muscle cells evoked by a number of agonists, including cholinomimetics and substance P, is often accompanied by an increase (repolarization and/or hyperpolarization) in the membrane potential. This change in membrane potential appears predominantly to reflect the action of an endothelial-derived hyperpolarizing factor (EDHF), which is distinct from NO (or endothelial-derived relaxing factor), and is discussed in this article by Chris Garland… CONTINUE READING

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