Endothelium-dependent effects of substance P and calcitonin gene-related peptide on mouse pial arterioles.

@article{Rosenblum1993EndotheliumdependentEO,
  title={Endothelium-dependent effects of substance P and calcitonin gene-related peptide on mouse pial arterioles.},
  author={W I Rosenblum and Takao Shimizu and G H Nelson},
  journal={Stroke},
  year={1993},
  volume={24 7},
  pages={1043-7; discussion 1047-8}
}
BACKGROUND AND PURPOSE The effects of substance P (SP) and calcitonin gene-related peptide (CGRP) were tested on pial arterioles of mice. This was done because (1) perivascular peptidergic nerves may play an important role in modulation of cerebrovascular responses; (2) there are conflicting data concerning the mechanism of action of CGRP; (3) there are few or no studies directly testing the endothelium dependence of dilation by these peptides in the cerebral circulation; and (4) we wished to… CONTINUE READING
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