Endothelium-dependent effects of halothane, enflurane, and isoflurane on isolated rat aortic vascular rings.

@article{Stone1989EndotheliumdependentEO,
  title={Endothelium-dependent effects of halothane, enflurane, and isoflurane on isolated rat aortic vascular rings.},
  author={David J. Stone and Roger A. Johns},
  journal={Anesthesiology},
  year={1989},
  volume={71 1},
  pages={126-32}
}
To determine the endothelium-dependent vascular effects of halothane, enflurane, and isoflurane, isometric tension was recorded in isolated ring preparations of rat thoracic aorta suspended in Kreb's buffer and aerated with 95% O2/5% CO2. One set of the rings had intact endothelium and the other set of the rings had the endothelium mechanically denuded. The rings were precontracted with phenylephrine (1 x 10(-6) M). Halothane, enflurane, or isoflurane gas was bubbled through the baths at… CONTINUE READING