Endothelium-dependent effects of cigarette smoke components on tone of porcine intrapulmonary arteries in vitro.

@article{Holden1990EndotheliumdependentEO,
  title={Endothelium-dependent effects of cigarette smoke components on tone of porcine intrapulmonary arteries in vitro.},
  author={W E Holden and Shirley S Kishiyama and Shin Pyung Dong and M. L. Osborne},
  journal={Toxicology and applied pharmacology},
  year={1990},
  volume={104 2},
  pages={191-9}
}
The acute effects of cigarette smoking on the pulmonary vasculature are poorly understood--both vasodilatory and vasoconstrictive effects have been described. To investigate the mechanisms involved, strips of pig intrapulmonary arteries with and without intact endothelium were exposed to an extract of cigarette smoke made by bubbling smoke through phosphate-buffered saline. After contraction with norepinephrine (2.5 X 10(-7) M), smoke extract (concentration range 0.001 to 0.5%) caused a… CONTINUE READING

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