Endothelium-dependent dilation to L-arginine in isolated rat skeletal muscle arterioles.

@article{Sun1992EndotheliumdependentDT,
  title={Endothelium-dependent dilation to L-arginine in isolated rat skeletal muscle arterioles.},
  author={Dong K. Sun and Edward J. Messina and A. E. Koller and Michael S. Wolin and Gabor Kaley},
  journal={The American journal of physiology},
  year={1992},
  volume={262 4 Pt 2},
  pages={
          H1211-6
        }
}
The vascular actions of L-arginine (L-Arg) were studied in isolated, pressurized first-order rat cremaster muscle arterioles (93 +/- 2.9 microns) bathed in a Krebs bicarbonate-buffered solution, pH 7.4, equilibrated with 21% O2-5% CO2. Arterioles were studied before and after either the administration of NG-nitro-L-arginine (L-NNA, 10(-3) M), an inhibitor of the synthesis of endothelium-derived relaxing factor (EDRF), or the removal of the endothelium. Acetylcholine (ACh, 10(-8) and 10(-6) M… CONTINUE READING
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