Endothelium-dependent L-Arg- and L-NMMA-sensitive mechanisms regulate tone of brain microvessels.

@article{Rosenblum1990EndotheliumdependentLA,
  title={Endothelium-dependent L-Arg- and L-NMMA-sensitive mechanisms regulate tone of brain microvessels.},
  author={W I Rosenblum and Hayato Nishimura and Guy H. Nelson},
  journal={The American journal of physiology},
  year={1990},
  volume={259 5 Pt 2},
  pages={H1396-401}
}
Pial arterioles on the surface of the mouse brain were observed via television microscopy and measured with an image-splitting technique. The vessels were dilated by L-arginine (L-Arg) in concentrations as low as 10(-5) M and were constricted in dose-dependent manner by NG-monomethyl-L-arginine (L-NMMA). Both the dilation and the constriction were abolished by endothelial damage. This damage was produced over a short segment of endothelium by a well-established technique that involves exposing… CONTINUE READING