Endothelium-Derived Hyperpolarizing Factor: Where Are We Now?

@article{Fltou2006EndotheliumDerivedHF,
  title={Endothelium-Derived Hyperpolarizing Factor: Where Are We Now?},
  author={M. F{\'e}l{\'e}tou and P. Vanhoutte},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={2006},
  volume={26},
  pages={1215-1225}
}
The endothelium controls vascular tone not only by releasing nitric oxide (NO) and prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth muscle cells. This characteristic was at the origin of the denomination endothelium-derived hyperpolarizing factor (EDHF). We know now that this acronym includes different mechanisms. In general, EDHF-mediated responses involve an increase in the intracellular calcium concentration, the opening of calcium-activated… Expand

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