Endothelium‐dependent vasorelaxation induced by L‐carnitine in isolated aorta from normotensive and hypertensive rats

@article{Herrera2002EndotheliumdependentVI,
  title={Endothelium‐dependent vasorelaxation induced by L‐carnitine in isolated aorta from normotensive and hypertensive rats},
  author={Mar{\'i}a Dolores Herrera and Rosario Bueno and Maria Alvarez de Sotomayor and Concepci{\'o}n P{\'e}rez-Guerrero and Carmen M V{\'a}zquez and Elisa Marhuenda},
  journal={Journal of Pharmacy and Pharmacology},
  year={2002},
  volume={54}
}
The aim of this work was to investigate the mechanism of the vasodilatory effect induced by L‐carnitine. Relaxation produced by L‐carnitine was studied in rat aortic rings with and without functional endothelium, pre‐contracted with phenylephrine by adding cumulative doses of L‐carnitine (10−7 to 10−3 M). The relaxation evoked by L‐carnitine reached higher values in aortic rings from spontaneously hypertensive rats than those obtained in arteries from normotensive rats; no relaxation was… Expand
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