Endothelins promote the activation of astrocytes in rat neostriatum through ET(B) receptors.

@article{Ishikawa1997EndothelinsPT,
  title={Endothelins promote the activation of astrocytes in rat neostriatum through ET(B) receptors.},
  author={Naoko Ishikawa and Motohiko Takemura and Yutaka Koyama and Yoshio Shigenaga and Takashi Okada and A. Ramesha Baba},
  journal={The European journal of neuroscience},
  year={1997},
  volume={9 5},
  pages={895-901}
}
The effects of endothelin (ET)-3 and an ET(B) receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala(1,3,11,15)-ET-1 (40 pmol), an ET(B) receptor agonist, also increased the number of striatal… CONTINUE READING

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