Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1.

@article{Conte2008EndothelinsMI,
  title={Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1.},
  author={Fernando de Paiva Conte and Christina Barja-Fidalgo and Waldiceu A Verri and Fernando Queiroz Cunha and Giles Alexander Rae and Carmen Penido and Maria G Henriques},
  journal={Journal of leukocyte biology},
  year={2008},
  volume={84 3},
  pages={652-60}
}
Endothelins (ETs) are involved in inflammatory events, including pain, fever, edema, and cell migration. ET-1 levels are increased in plasma and synovial membrane of rheumatoid arthritis (RA) patients, but the evidence that ETs participate in RA physiopathology is limited. The present study investigated the involvement of ETs in neutrophil accumulation and edema formation in the murine model of zymosan-induced arthritis. Intra-articular (i.a.) administration of selective ET(A) or ET(B) receptor… CONTINUE READING