Endothelins inhibit luteinization of cultured porcine granulosa cells.

  title={Endothelins inhibit luteinization of cultured porcine granulosa cells.},
  author={Masaki Iwai and Masaaki Hasegawa and Shunzou Taii and Norimasa Sagawa and Kohshiro Nakao and Hiroo Imura and Setsuko Nakanishi and Takahide Mori},
  volume={129 4},
Endothelin (ET), a novel vasoconstrictor peptide containing three isopeptides [ET-1, ET-2, and ET-3 (ETs)], has various biological effects including vasoconstriction, mitogenesis, and steroidogenesis. We examined the ET-1-like immunoreactivity level in porcine follicular fluid and culture medium of porcine granulosa cells by RIA. The ET level in the follicular fluid was 9.4-14.2 pg/ml. These levels were within 0.42 to 0.62-fold of the porcine plasma level (22.7 +/- 3.1 pg/ml) (mean +/- SE). ET… CONTINUE READING


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