Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum.

@article{Sullivan1996EndothelinsIF,
  title={Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum.},
  author={Anne M. Sullivan and A. Jennifer Morton},
  journal={Journal of neurochemistry},
  year={1996},
  volume={67 4},
  pages={1409-18}
}
Endothelins (ETs) and their receptors are present in high levels in the brain and have been proposed to act as neuromodulators or neurotransmitters. However, neither their role nor their precise mechanism of action in the brain is understood. In this study, c-fos expression was used as a marker of neuronal activation in organotypic cultures of rat cerebellum. ETs induced Fos protein expression in both granule cells and glia but not in Purkinje cells. Granule cells and glia were both very… CONTINUE READING