Endothelins control the timing of Schwann cell generation in vitro and in vivo.

@article{Brennan2000EndothelinsCT,
  title={Endothelins control the timing of Schwann cell generation in vitro and in vivo.},
  author={Angela A. Brennan and Charlotte H Dean and An Ling Zhang and Daniel Thomas Cass and Rhona Mirsky and Kristj{\'a}n R. Jessen},
  journal={Developmental biology},
  year={2000},
  volume={227 2},
  pages={545-57}
}
Schwann cell precursors, derivatives of the neural crest, generate Schwann cells in a process that is tightly timed, well characterized, and directly controlled by axonal signals, in particular beta-neuregulins. Here we provide evidence that endothelins (ETs) are also important for survival and lineage progression in this system. We show that ETs promote rat Schwann cell precursor survival in vitro without stimulation of DNA synthesis. Using ET receptor agonists and antagonists, we demonstrate… CONTINUE READING

From This Paper

Topics from this paper.
26 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…