Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice.

@article{Piovezan2004EndothelinsCT,
  title={Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice.},
  author={Anna Paula Piovezan and Pedro D'Orl{\'e}ans-Juste and Monica Frighetto and Gl{\'o}ria Em{\'i}lia Petto Souza and Maria G Henriques and Giles Alexander Rae},
  journal={British journal of pharmacology},
  year={2004},
  volume={141 4},
  pages={755-63}
}
1. The contribution of endogenous endothelins to nociceptive responses elicited by ovalbumin (OVA) in the hind-paw of mice sensitised to this antigen (50 microg OVA+5 mg Al(OH)(3), s.c., 14 days beforehand) was investigated. 2. Sensitised mice exhibited greater nocifensive responsiveness to intraplantar (i.pl.) OVA (total licking time over first 30 min: 85.2+/-14.6 s at 0.3 microg; 152.6+/-35.6 s at 1 microg) than nonsensitised animals (29.3+/-7.4 s at 1 microg). Nocifensive responses of… CONTINUE READING

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