• Corpus ID: 42797350

EndothelinA Receptor Subtype Mediates Endothelin-Induced Contractility in Left Ventricular Cardiomyocytes Isolated from Rabbit Myocardium 1

  title={EndothelinA Receptor Subtype Mediates Endothelin-Induced Contractility in Left Ventricular Cardiomyocytes Isolated from Rabbit Myocardium 1},
  author={Elizabeth J. Kelso and Barbara J. McDermott and Bernard Silke and James Paul Spiers},
Endothelin (ET)-1 is a potent positive inotropic agent, the effects of which are mediated by increases in cytosolic Ca in the myocardium. The object of this study was to examine 1) the influence of ETA and ETB receptor subtypes, and 2) the role of the phospholipase C (PLC) pathway in mediating ET-1-induced contraction. Left ventricular cardiomyocytes were isolated from the hearts of New Zealand White rabbits (2–2.5 kg) by the use of Langendorff perfusion with collagenase. Cardiomyocyte function… 

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